Vikipedi özgür ansiklopedi HMG CoA AdlandırmalarIUPAC adı 9R 21S 1 2R 3S 4R 5R 5 6 amino 9H purin 9 il 4 hidroksi 3 fosf

Vikipedi ozgur ansiklopedi HMG CoA AdlandirmalarIUPAC adi 9R 21S 1 2R 3S 4R 5R 5 6 amino 9H purin 9 il 4 hidroksi 3 fosfonooksi tetrahidrofuran 2 il 3 5 9 21 tetrahidroksi 8 8 21 trimetil 10 14 19 triokso 2 4 6 trioksa 18 tiya 11 15 diaza 3 5 difosfatrikozan 23 oik asit 3 5 dioksitDiger adlar3 hidroksi 3 metilglutaril CoA 3 hidroksi 3 metilglutaril koenzim ATanimlayicilarCAS numarasi 1553 55 5 3D model JSmol Etkilesimli goruntuChEBI CHEBI 61659 ChemSpider 392859 ECHA InfoCard 100 014 820IUPHAR BPS 3040MeSH HMG CoAPubChem CID 445127CompTox Bilgi Panosu EPA DTXSID40862689 DTXSID00935181 DTXSID40862689InChI InChI 1S C27H44N7O20P3S c1 26 2 21 40 24 41 30 5 4 15 35 29 6 7 58 17 38 9 27 3 42 8 16 36 37 11 51 57 48 49 54 56 46 47 50 10 14 20 53 55 43 44 45 19 39 25 52 14 34 13 33 18 22 28 31 12 32 23 18 34 h12 14 19 21 25 39 40 42H 4 11H2 1 3H3 H 29 35 H 30 41 H 36 37 H 46 47 H 48 49 H2 28 31 32 H2 43 44 45 t14 19 20 21 25 27 m1 s1 Key CABVTRNMFUVUDM VRHQGPGLSA N InChI 1 C27H44N7O20P3S c1 26 2 21 40 24 41 30 5 4 15 35 29 6 7 58 17 38 9 27 3 42 8 16 36 37 11 51 57 48 49 54 56 46 47 50 10 14 20 53 55 43 44 45 19 39 25 52 14 34 13 33 18 22 28 31 12 32 23 18 34 h12 14 19 21 25 39 40 42H 4 11H2 1 3H3 H 29 35 H 30 41 H 36 37 H 46 47 H 48 49 H2 28 31 32 H2 43 44 45 t14 19 20 21 25 27 m1 s1Key CABVTRNMFUVUDM VRHQGPGLBXSMILES O C O C C O C CC O SCCNC O CCNC O C H O C C C COP O O OP O O OC C H 3O C H n2cnc1c ncnc12 N C H O C H 3OP O O OOzelliklerMolekul formulu C27H44N7O20P3SMolekul kutlesi 911 661 g molAksi belirtilmedigi surece madde verileri Standart sicaklik ve basinc kosullarinda belirtilir 25 C 77 F 100 kPa dogrula Bilgi kutusu kaynaklari b Hidroksi b metilglutaril CoA HMG CoA nam i diger 3 hidroksi 3 metilglutaril koenzim A mevalonat ve ketogenez yolunun ara urunlerinden biridir Asetil CoA ve nin ile katalizlenmesi ile olusur ve in 1950 lerde Illinois Universitesinde yuruttugu calismalar ile kesfedilmistir HMG CoA dallanmis zincirli aminoasit olan losin izolosin ve valin metabolizmasinin ara urunudur Metabolizmada hemen oncesindeki ara urunler b metilglutakonil CoA MG CoA ve b hidoksi b metilbutiril CoA HMB CoA idir HMG CoA reduktaz HMG CoA nin donusmesini katalizler kolesterol biyosentezi icin zorunlu bir reaksiyondur Mevalonat yolu span sentezi iki asetil CoA nin enziminin katalizlenip yi olusturmasi ile baslar Muteakip reaksiyonda ise enzimi asetil CoA ve nin birlesmesinin katalizleyerek HMG CoA nin olusmasini saglar biyosentezinin son basamaginda bir NADPH bagimli oksidoreduktaz olan HMG CoA reduktaz HMG CoA nin mevalonata donusmesini katalizler Bu basamak yolun ilk kontrol noktasidir Mevalonat Insan da kolesterol dahil olmak uzere bircok son urune katilan izoprenoid gruplarinin prekursorudur Mevalonat yoluKetogenez yolu span HMG CoA liyaz HMG CoA yi asetil CoA ve asetoasetata parcalanmasini katalizler Biyosentez span L Losin Glutamat Glutamat Alanin Piruvat Kas a KIC Karaciger a KIC mitokondri sitozol HMB idrar ile ekskre edilir 10 40 b Hidroksi b metilglutaril CoA HMG CoA MC CoA MG CoA CO2 CO2 O2 CO2 CO2 karaciger HMG CoA liyaz HMG CoA reduktaz Mevalonat yolu Bilinmeyen bir enzim Asetil CoA Kolesterol a Insanin L losin e gore ve icin metabolik yollari Bu iki ana yolda L Losinin cogu izovaleril CoA ya metabolize olurken sadece 5 i HMB ye metabolize olur a Bu reaksiyon bilinmeyen bir enzimi tarafindan katalizlenmektedir Ayrica bakiniz span Kaynakca span Wayback Machine PDF www nmji in 31 Mayis 2016 tarihinde kaynagindan PDF arsivlendi Erisim tarihi 3 Agustos 2025 Surolia Avadhesha 1 Haziran 1997 Obituary An outstanding scientist and a splendid human being Prof Bimal Kumar Bachhawat Glycobiology 7 4 453 doi 10 1093 glycob 7 4 453 ISSN 0959 6658 KEGG PATHWAY Valine leucine and isoleucine degradation Reference pathway www kegg jp Erisim tarihi 3 Agustos 2025 Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Wilson Jacob M Fitschen Peter J Campbell Bill Wilson Gabriel J Zanchi Nelo Taylor Lem Wilborn Colin Kalman Douglas S Stout Jeffrey R Hoffman Jay R Ziegenfuss Tim N 2 Subat 2013 International Society of Sports Nutrition Position Stand beta hydroxy beta methylbutyrate HMB Journal of the International Society of Sports Nutrition 10 1 6 doi 10 1186 1550 2783 10 6 PMC 3568064 2 PMID 23374455 Zanchi Nelo Eidy Gerlinger Romero Frederico Guimaraes Ferreira Lucas de Siqueira Filho Mario Alves Felitti Vitor Lira Fabio Santos Seelaender Marilia Lancha Antonio Herbert 1 Nisan 2011 HMB supplementation clinical and athletic performance related effects and mechanisms of action Amino Acids Ingilizce 40 4 1015 1025 doi 10 1007 s00726 010 0678 0 ISSN 1438 2199 Kohlmeier Martin 12 Mayis 2015 Nutrient Metabolism Structures Functions and Genes Ingilizce Academic Press ss 385 388 ISBN 978 0 12 387788 8 Energy fuel Eventually most Leu is broken down providing about 6 0kcal g About 60 of ingested Leu is oxidized within a few hours Ketogenesis A significant proportion 40 of an ingested dose is converted into acetyl CoA and thereby contributes to the synthesis of ketones steroids fatty acids and other compounds Garrett RH Biochemistry Cengage Learning s 856 ISBN 978 1 305 57720 6 Haines Brandon E Steussy C Nicklaus Stauffacher Cynthia V Wiest Olaf 9 Ekim 2012 Molecular Modeling of the Reaction Pathway and Hydride Transfer Reactions of HMG CoA Reductase Biochemistry 51 40 7983 7995 doi 10 1021 bi3008593 ISSN 0006 2960 PMC 3522576 2 PMID 22971202 KEGG REACTION R10759 www genome jp Erisim tarihi 2025 08 03 Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Mock Donald M Stratton Shawna L Horvath Thomas D Bogusiewicz Anna Matthews Nell I Henrich Cindy L Dawson Amanda M Spencer Horace J Owen Suzanne N Boysen Gunnar Moran Jeffery H 2011 11 01 Urinary Excretion of 3 Hydroxyisovaleric Acid and 3 Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin Deficient Humans12 The Journal of Nutrition 141 11 1925 1930 doi 10 3945 jn 111 146126 ISSN 0022 3166 3HIA carnitine is thought to be either directly deacylated by a hydrolase to 3HIA or to undergo a second CoA exchange to again form 3 hydroxyisovaleryl CoA followed by release of 3HIA and free CoA by a thioesterase gtdKolesterol ve SteroidlerinMevalonat yoluHMG CoA yaAsetil CoA HMG CoAKeton cisimcikleriAseton Asetoasetik asit ye Geranil Karotenoid Kolesterole Kolesterol Kolesterolden Steroid hormonlarina da bakiniz Insan hariciSitosterol e Sitosterol Daha fazla Fitosterol icin bakiniz Ergokalsiferol e Ergokalsiferol gtdAmino asit Asetil KoALizin Sakaropin Losin Triptofan Alanin Antranilik asit G Piruvat SitratGlisin Serin Glisin Kreatin KreatininG Glutamat Histidin Prolin Arjinin Ornitin DigerSistein Glutamat Glutatyon g GlutamilsisteinG Valin Izolosin Metiyonin Homosistein uretimi Sisteine donusum SisteinTreonin G FumaratFenilalanin Tirozin G ure siklusuna bakinizDiger Kategoriler Biyokimya taslaklariGizli kategoriler Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddelerVikiveri den ECHA InfoCard kimligiTanimlanmamis parametreler iceren kimya bilgi kutusu kullanilan sayfalar