U 50488 oldukça seçici bir agonisti olarak işlev gören ancak herhangi bir antagonist etkisi olmayan bir ilaçtır Analjezi

U-50488, oldukça seçici bir agonisti olarak işlev gören, ancak herhangi bir antagonist etkisi olmayan bir ilaçtır.Analjezik, idrar söktürücü ve öksürük kesici etkileri vardır ve antikolinerjik ilaçlar tarafından üretilen hafıza bozukluğunu tersine çevirir. U-50488, icat edilen ilk seçici kappa agonistlerinden biridir ve türevleri üzerine yapılan araştırmalar, ilgili bileşikler ailesinin geliştirilmesine yol açmıştır. Bu bileşik hiçbir zaman FDA onayı almamıştır.

U-50488
Tanımlayıcılar


CAS Numarası	67198-13-4
PubChem CID	3036289
CompTox Bilgi Paneli (EPA)	DTXSID60953023
Kimyasal ve fiziksel veriler
Formül	C₁₉H₂₆Cl₂N₂O

Kaynakça

^ "U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 6 (4–6): 467-70. 1982. doi:10.1016/S0278-5846(82)80130-9. (PMID) 6298890.
^ "Role of opioidergic and serotonergic mechanisms in cough and antitussives". Pulmonary Pharmacology. 9 (5–6): 349-56. 1996. doi:10.1006/pulp.1996.0046. (PMID) 9232674.
^ "Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models". Methods and Findings in Experimental and Clinical Pharmacology. 20 (7): 595-9. September 1998. doi:10.1358/mf.1998.20.7.485724. (PMID) 9819804.
^ "U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990". Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques. 52: 167-95. 1999. doi:10.1007/978-3-0348-8730-4_4. (PMID) 10396128.
^ "U-50,488 and the kappa receptor. Part II: 1991-1998". Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques. 53: 1-51. 1999. (PMID) 10616295.
^ "Addressing Hazards from Unscheduled Novel Psychoactive Substances as Research Chemicals: The Case of U-50488". Cureus. 9 (12): e1914. December 2017. doi:10.7759/cureus.1914. (PMC) 5800751 $2. (PMID) 29441248.

[1] "U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 6 (4–6): 467-70. 1982. doi:10.1016/S0278-5846(82)80130-9. (PMID) 6298890.

[2] "Role of opioidergic and serotonergic mechanisms in cough and antitussives". Pulmonary Pharmacology. 9 (5–6): 349-56. 1996. doi:10.1006/pulp.1996.0046. (PMID) 9232674.

[3] "Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models". Methods and Findings in Experimental and Clinical Pharmacology. 20 (7): 595-9. September 1998. doi:10.1358/mf.1998.20.7.485724. (PMID) 9819804.

[4] "U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990". Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques. 52: 167-95. 1999. doi:10.1007/978-3-0348-8730-4_4. (PMID) 10396128.

[5] "U-50,488 and the kappa receptor. Part II: 1991-1998". Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques. 53: 1-51. 1999. (PMID) 10616295.

[6] "Addressing Hazards from Unscheduled Novel Psychoactive Substances as Research Chemicals: The Case of U-50488". Cureus. 9 (12): e1914. December 2017. doi:10.7759/cureus.1914. (PMC) 5800751 $2. (PMID) 29441248.